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Zhongtongning (often referenced as Shuanghu Zhongtongning) is a traditional Chinese medicine formulation available as a tincture or spray. It is described as a brownish-yellow liquid with a slightly fragrant smell. The primary indications are to remove blood stasis, promote qi circulation, and relieve pain. Network pharmacology and UPLC-Q-TOF-MS/MS studies suggest it contains multiple herbal components with potential analgesic effects[2][3]. Its mechanism of action likely involves multi-target modulation typical of traditional Chinese medicine formulas; however, specific molecular targets are not clearly defined in the literature.
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