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Zhubech
- Development stage
- Preclinical
- Lead developer
- Florida Agricultural and Mechanical University
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
Zhubech is a liposomal nanoparticle formulation of 1,3-bistertrahydrofuran-2yl-5FU (MFU), a derivative of the antimetabolite 5-fluorouracil (5-FU). Developed to address the high toxicity and resistance associated with conventional 5-FU therapy, Zhubech utilizes a nanocarrier system to improve drug stability, release kinetics, and biodistribution. In preclinical studies, Zhubech demonstrated significantly enhanced anticancer activity compared to standard 5-FU and the free MFU analog in pancreatic cancer models, including 3D spheroids, organoids, and patient-derived xenograft (PDX) mouse models. The formulation aims to provide a more effective and less toxic delivery mechanism for treating pancreatic ductal adenocarcinoma.
- Other names
- MFU-loaded liposomal nanoparticles1,3-bistertrahydrofuran-2yl-5FU liposomal formulation
02
Targets
TS (Thymidylate synthase)
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