Drug intelligence / Profile preview

Zhuijianpan Decoction

Development stage
Preclinical
Lead developer
Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University
Modality
Small Molecules
Administration
Oral
01

Overview

Zhuijianpan Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by the Affiliated TCM Hospital of Guangzhou Medical University specifically for the treatment of lumbar disc herniation (LDH). The formula is designed to address the Liver and Kidney deficiency and Blood stasis patterns often associated with chronic back pain and radiculopathy in TCM theory. It typically comprises a blend of medicinal herbs such as Dipsaci Radix, Taxilli Herba, and Eucommiae Cortex, which are traditionally used to strengthen the musculoskeletal system and promote circulation. Clinically, Zhuijianpan Decoction is employed to reduce inflammatory responses at the site of disc protrusion, alleviate pressure-induced nerve pain, and improve the functional status of patients. Research suggests its mechanism involves the downregulation of pro-inflammatory mediators like tumor necrosis factor and various interleukins, contributing to its analgesic and anti-inflammatory profile. Clinical efficacy is often measured by improvements in the Visual Analogue Scale (VAS) for pain and the Japanese Orthopaedic Association (JOA) scores for functional mobility.

Other names
Zhuijianpan TangZhuijianpan Fang椎间盘方
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)

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