Drug intelligence / Profile preview

Zhulong Huoxuetongyu granules

Development stage
Unknown
Lead developer
Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Zhulong Huoxuetongyu granules (also referred to as Zhilong Huoxuetongyu granules) is a Traditional Chinese Medicine (TCM) hospital preparation developed by the Hospital of Traditional Chinese Medicine affiliated to Southwest Medical University. It is specifically formulated for the treatment of acute ischemic stroke characterized by the TCM syndrome of Qi deficiency and blood stasis. The formulation is designed to invigorate blood circulation and resolve blood stasis (Huoxue Tongyu), utilizing active components from ingredients such as Leech (Shuizhi) and Earthworm (Dilong). The drug is currently being evaluated in Phase 1 clinical trials in China to assess its efficacy and safety as an adjunctive therapy to standard basic treatment for patients with cerebral infarction.

Other names
Zhilong Huoxuetongyu granulesZhilong Huoxue Tongyu granulesZhulong Huoxuetongyu keli猪龙活血通瘀颗粒蛭龙活血通瘀颗粒
02

Targets

NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)Fibrin (Factor Ia)F2 (Thrombin)MAPK14 (p38 mitogen-activated protein kinase alpha)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)TLR4 (Toll-like receptor 4)

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