Zi-Yin-Liang-Ge-San

Zi-Yin-Liang-Ge-San appears to be a variant of Liang-Ge-San (LGS), a classic traditional Chinese medicine formula first described in *Taiping Huimin Heji Jufang* (Song dynasty, c. 1107 AD). It contains multiple herbs, with Forsythia Fruits (Lian Qiao) as the principal ingredient. The formula is designed to clear heat and fire according to traditional Chinese medicine principles. It is widely used to treat various inflammatory conditions including: - Acute lung injury - Pharyngitis - Amygdalitis - Pneumonia - Sepsis Research has shown that Liang-Ge-San exerts potent anti-inflammatory effects through several mechanisms, such as: 1. Suppressing the production of pro-inflammatory cytokines IL-6 and TNF-α. 2. Inhibiting the degradation and phosphorylation of IκBα and the nuclear translocation of NF-κB p65. 3. Activating the α7 nicotinic cholinergic receptor (α7nAchR). 4. Up-regulating miR-21 expression, leading to suppression of the STAT3 signaling pathway. 5. Potentially inhibiting glycogen synthase kinase-3β (GSK-3β). For adult patients, the typical dosage mentioned is 200 ml of Liang-Ge-San decoction at a concentration of 0.195 g/ml, taken orally twice per day. The formula is also available in various forms, including pills marketed under names like "Cool Valley" (Liang Ge San Wan).

Brand names

Cool Valley

Other names

Liang-Ge-SanLGS