zibrofusidic acid

**Zibrofusidic acid** is a brominated derivative of fusidic acid, a steroidal antibiotic, with the chemical formula C31H47BrO6. It is a **small molecule** researched primarily as a research tool for studying bacterial multidrug efflux pumps due to its structural modification at the 24-position with a bromine atom, potentially altering its pharmacokinetic properties or resistance profile compared to parent fusidic acid. Fusidic acid inhibits bacterial protein synthesis by preventing the turnover of elongation factor G (EF-G) from the ribosome, primarily targeting Gram-positive bacteria like *Staphylococcus aureus*; zibrofusidic acid likely retains a similar **mechanism of action** but has been investigated in clinical trials for topical treatment of skin infections such as impetigo and secondarily infected traumatic lesions (SITL).

Other names

24-bromofusidic acid