Drug intelligence / Profile preview

zinc tetra-ascorbo-camphorate

Development stage
Phase 2
Lead developer
MGB Biopharma
Modality
Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Zinc tetra-ascorbo-camphorate (C14) is a synthetic monoterpenoid derivative that consists of a terpenoid system stably associated with four ascorbic acid molecules via a central zinc atom. It belongs to the broader family of terpenoids, which are known for diverse pharmacological properties including anticancer, analgesic, anti-inflammatory, immunomodulatory, and antiviral activities. C14 has demonstrated broad-spectrum antiviral activity in vitro against viruses such as HIV, HSV (herpes simplex virus), and HPV (human papillomavirus). Its mechanism of action is not fully elucidated but includes potent inhibition of early stages in the viral replication cycle—specifically entry or pre-integration steps for HIV. Preclinical studies have shown that C14 can inhibit infection in primary immune cells without significant cytotoxicity or mucosal toxicity at therapeutic concentrations. The compound is being developed primarily as a topical microbicide candidate for prevention and treatment of sexually transmitted viral infections such as HIV and HPV-associated cervical lesions[1][2][3][4][7].

Brand names
C14C-14C 14
Other names
zinc monoterpenoid tetra-ascorbo-camphoratemonoterpenoid zinc tetra-ascorbo-camphorate

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