Drug intelligence / Profile preview

Zinthionein ZC

Development stage
Unknown
Lead developer
Theriva Biologics
Modality
Small Molecules
Administration
Oral
01

Overview

**Zinthionein ZC** was Adeona Pharmaceuticals' proprietary once-daily, gastroretentive, sustained-release oral medical-food candidate for dietary management of Alzheimer's disease and mild cognitive impairment. The fixed-dose tablet contains zinc acetate providing 150 mg elemental zinc plus 100 mg cysteine. It was designed to improve zinc bioavailability and tolerability relative to conventional zinc acetate capsules while lowering serum non-ceruloplasmin copper; cysteine was included for antioxidant support and its role in metallothionein, a copper- and zinc-binding protein. The product was subsequently renamed **reaZin** during its clinical development. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01099332))

Brand names
reaZin
Other names
reaZinZinthioneinZinthionein ZC
02

Targets

NeuraminidaseGPX4 (Glutathione peroxidase 4)

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