Zishen Jianpi Huayu

Zishen Jianpi Huayu is a traditional Chinese medicine (TCM) formula, most commonly available as a tablet formulation. It is composed of multiple herbal ingredients and is used primarily for the adjunctive treatment of diabetic complications such as diabetic retinopathy and chronic renal insufficiency. The mechanism of action involves modulation of inflammatory pathways and vascular factors; key active components include quercetin, kaempferol, and rehmannia flavonoids. These act on targets such as interleukin-1β (IL-1β), interleukin-6 (IL-6), vascular endothelial growth factor A (VEGFA), AKT1, TP53, and are involved in signaling pathways like NF-κB, AGE-RAGE, and PI3K-AKT. Experimental studies have shown that the formula can reduce inflammation in human retinal microvascular endothelial cells under high-glucose conditions[2]. Clinical studies suggest efficacy in improving kidney function parameters in chronic renal insufficiency[3]. The product is developed within the framework of TCM by various Chinese research institutions but specific commercial developers or manufacturers are not clearly identified from available sources.

Brand names

Zishen Jianpi Huayu Tablet

Other names

滋肾健脾化瘀片Zishen Jianpi Huayu Tablets