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Zishen Tongluo Formula
- Development stage
- Preclinical
- Lead developer
- Nanjing University of Chinese Medicine
- Administration
- Oral
01
Overview
Zishen Tongluo Formula (ZTF) is an oral Traditional Chinese Medicine (TCM) herbal formulation developed by Nanjing University of Chinese Medicine for the treatment of rheumatoid arthritis. It is a simplified version of the Qingluo Tongbi formula, which was originally created by Professor Zhou Zhongying and has been used clinically for several decades. ZTF is composed of five herbal ingredients: *Tripterygium wilfordii* Hook.f., *Bombyx mori* L., *Sinomenium acutum* (Thunb.) Rehder & E.H.Wilson, *Rehmannia glutinosa* (Gaertn.) DC., and *Panax notoginseng* (Burkill) F.H.Chen. Preclinical research in collagen-induced arthritis (CIA) mouse models has demonstrated that ZTF improves joint inflammation and reduces pro-inflammatory cytokine levels by restoring the balance between T-helper 17 (Th17) cells and regulatory T (Treg) cells.
- Other names
- Zishen Tongluo
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