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Zisheng Wan is a traditional Chinese medicine (TCM) herbal formula traditionally used to strengthen the spleen, harmonize the stomach, and treat digestive disorders such as indigestion and chronic diarrhea. In modern clinical research, it is being investigated for its potential to alleviate targeted drug-associated diarrhea (TDAD) in patients with non-small cell lung cancer (NSCLC) receiving therapies such as EGFR tyrosine kinase inhibitors. The formula typically comprises a complex mixture of herbs including *Panax ginseng*, *Atractylodes macrocephala*, and *Poria cocos*, which are thought to improve gastrointestinal function, protect the intestinal mucosal barrier, and modulate the gut microbiota.
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