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Zishui Qinggan Lichong Decoction
- Development stage
- Preclinical
- Administration
- Oral
01
Overview
Zishui Qinggan Lichong Decoction is a traditional Chinese medicine (TCM) herbal formula used primarily for gynecological and endocrine disorders, particularly in women with perimenopausal syndrome and ovarian dysfunction. It is a multi-herb decoction formulated according to TCM principles, aiming to nourish yin, clear the liver, and resolve blood stasis. Clinical studies suggest it may improve ovarian function in perimenopausal women[1]. The mechanism of action is believed to involve modulation of hormonal levels (such as estradiol, progesterone, follicle-stimulating hormone, and luteinizing hormone), inhibition of micro-angiogenesis by downregulating hypoxia-inducible factor 1-alpha (HIF-1α) and vascular endothelial growth factor (VEGF), as well as anti-inflammatory effects[3]. The decoction may also have neuroprotective effects via regulation of synaptic plasticity and mitochondrial function through PGC-1α signaling pathways[4].
- Other names
- Zishui Qinggan Lichong Decoction
02
Targets
IL8 (C-X-C Motif Chemokine Ligand 8)VEGFA (Vascular endothelial growth factor A)HIF1A (Hypoxia-inducible factor 1-alpha)AKT (RAC-alpha serine/threonine-protein kinase)
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