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ziyinxiehuo
- Development stage
- Phase 4
- Lead developer
- Children's Hospital of Fudan University
- Administration
- Oral
01
Overview
Ziyinxiehuo is a Traditional Chinese Medicine (TCM) herbal formula developed by the Children's Hospital of Fudan University for the treatment of idiopathic precocious puberty (IPP) in children, particularly girls. Based on the TCM principle of "nourishing Yin and purging fire" (Ziyin Xiehuo), the formula aims to address the underlying pattern of Yin deficiency and fire hyperactivity, which is believed to contribute to the premature activation of the hypothalamic-pituitary-gonadal (HPG) axis. It is typically administered as granules and has been studied both as a monotherapy and in combination with acupuncture to slow bone age progression and regulate hormone levels.
- Other names
- Ziyinxiehuo GranulesZiyin-Xiehuo Chinese Medicine HerbsZiyin Xiehuo
02
Targets
LH (Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1)GnRH (Gonadotropin-releasing hormone 2)
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