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ZKY001 is an investigational topical ophthalmic peptide drug developed by Zhaoke Ophthalmology for corneal epithelial repair. It is formulated as an eye drop containing a seven-amino-acid peptide derived from the functional fragment of thymosin beta 4, an actin-binding peptide implicated in cell migration, cytoskeletal organization, and wound healing. The program has primarily targeted corneal epithelial defects and has also been explored in other corneal repair settings such as transepithelial photorefractive keratectomy, pterygium, and neurotrophic keratitis. Available company pipeline information places ZKY001 in Phase 2 development for corneal epithelial defects, with later strategic focus reported on transepithelial photorefractive keratectomy as a subsequent development indication.
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