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ZL-1311
- Development stage
- Preclinical
- Lead developer
- Zai Lab
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
ZL-1311 is a T-cell engager (TCE) designed to target Mucin-17 (MUC17), a cell surface protein that is significantly overexpressed in gastrointestinal malignancies, particularly gastric and gastroesophageal junction (GEJ) cancers. Developed by Zai Lab, ZL-1311 is a bispecific molecule engineered to simultaneously bind to MUC17 on tumor cells and the CD3 receptor on T cells. This dual binding facilitates the formation of an immunological synapse, leading to T-cell activation and the directed lysis of MUC17-expressing cancer cells. Zai Lab holds exclusive worldwide rights for the development and commercialization of this program, which is slated to enter global clinical trials in 2026.
02
Targets
CD3 (T-cell surface glycoprotein CD3)MUC17 (Mucin 17, cell surface associated)
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