Drug intelligence / Profile preview

ZM-H1505R + entecavir

Development stage: Unknown
Lead developer: Shanghai Zhimeng Biopharma
Modality: Small Molecules
Administration: Oral

Overview

ZM-H1505R + entecavir is an investigational **oral combination therapy** for chronic hepatitis B virus (HBV) infection. It consists of ZM-H1505R (also known as canocapavir), a novel small molecule HBV capsid assembly modulator (core protein allosteric modulator, CAM-E type), and entecavir, a widely used nucleoside analog reverse transcriptase inhibitor. ZM-H1505R binds a unique site on the HBV core protein, hindering pre-genomic RNA (pgRNA) packaging and effectively blocking the formation of covalently closed circular DNA (cccDNA), thus disrupting HBV replication. Entecavir inhibits the reverse transcription of viral RNA into DNA. The combination is being developed to enhance the antiviral effect versus entecavir monotherapy and to potentially overcome resistance to existing therapies.

Other names: ZM-H1505R + ETV

Targets

HBV Pol (Hepatitis B virus polymerase)HBc (Hepatitis B virus core protein)

Beyond the preview

Go deeper on ZM-H1505R + entecavir.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on ZM-H1505R + entecavir.

Explore the full profile