ZM336372

**ZM336372** is a synthetic small molecule originally identified as a potent, specific, and reversible inhibitor of the protein kinase c-Raf (RAF1), with an IC50 of 70 nM[2][3]. In cell systems, ZM336372 paradoxically acts as a c-Raf (RAF1) activator, especially in neuroendocrine tumor (NET) and hepatic carcinoma cell lines, leading to activation of the Raf-1/MEK/ERK pathway and subsequent inhibition of tumor cell growth[1][5]. ZM336372 also inactivates glycogen synthase kinase-3 beta (GSK-3β) via phosphorylation and reduces neuroendocrine tumor markers in a manner partly independent of ERK pathway activation[1]. It has also been shown to inhibit SAPK2/p38β2 (IC50 ~2 μM)[3]. ZM336372 is used exclusively in research settings and is not approved for human or veterinary use[2]. Primary indications explored in the literature include neuroendocrine tumors and hepatocellular carcinoma cell proliferation[1][5].

Other names

N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide