ZMC1

ZMC1 (Zinc Metallochaperone-1), also known as NSC319726, is a small molecule mutant p53 reactivator developed by researchers at Rutgers University. It functions as a zinc ionophore that increases intracellular zinc concentrations and facilitates the refolding of zinc-deficient mutant p53 proteins (specifically the R175H human mutation, which corresponds to R172H in mice) into their active, wild-type-like conformation. This restoration of p53 function triggers the transcription of pro-apoptotic genes and induces cell death in cancer cells. ZMC1 has demonstrated efficacy in preclinical models of pancreatic and ovarian cancers harboring specific p53 mutations, and its activity can be further enhanced when complexed with zinc (forming Zn-1).

Other names

Zinc metallochaperone-1