ZMF-28

ZMF-28: sourced facts only. name: "We identified ZMF-28, a potent PAK1 inhibitor with an IC50 of 0.02 μM, exhibiting high selectivity in the kinase profiling assay." [PMID:42748864]; target: "We identified ZMF-28, a potent PAK1 inhibitor with an IC50 of 0.02 μM, exhibiting high selectivity in the kinase profiling assay." [PMID:42748864]; developer: "College of Pharmacy, Shenzhen Technology University, Shenzhen, 518118, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518060, China." [PMID:42748864]; stage: "Notably, ZMF-28 exhibited 10-fold higher cellular antiproliferative activity against 4T1 cells (IC50 = 0.22 μM) than the clinical candidate FRAX-486, and achieved significant tumor growth inhibition in vivo without overt toxicity, and demonstrated favorable pharmacokinetics." [PMID:42748864]