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ZMIZ1 shRNA
- Development stage
- Preclinical
- Lead developer
- Shanghai Jiao Tong University
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
ZMIZ1 shRNA is a short hairpin RNA designed to target and silence the expression of the ZMIZ1 (Zinc finger MIZ-type containing 1) gene. ZMIZ1 functions as a SUMO E3 ligase and a transcriptional co-regulator of the Protein Inhibitor of Activated STAT (PIAS)-like family. In the context of acute myeloid leukemia (AML), ZMIZ1 is often highly expressed and associated with unfavorable clinical outcomes. By utilizing RNA interference to knock down ZMIZ1, researchers have demonstrated suppressed cell viability, induced apoptosis, and enhanced sensitivity to chemotherapy (such as Ara-C) in various AML cell lines. Mechanistically, ZMIZ1 appears to drive leukemogenesis by regulating essential transcription factors like MYB, and its inhibition disrupts the transcriptional programs necessary for leukemia cell proliferation and survival.
- Other names
- sh-ZMIZ1sh-ZMIZ-1sh-ZMIZ 1ZMIZ1 knockdownZMIZ-1 knockdownZMIZ 1 knockdown
02
Targets
ZMIZ1 (Zinc finger MIZ domain-containing protein 1)
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