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ZN-c3 (Barrow Neurological Inst.)
- Development stage
- Preclinical
- Lead developer
- Barrow Neurological Institute
01
Overview
ZN-c3 (Barrow Neurological Inst.): sourced facts only. name: "The median unbound concentrations of ZN-c3 were 315 nmol/L and 15 nmol/kg in plasma and tumor tissue, respectively - higher than the biochemical IC50 of ZN-c3 for inhibition of WEE1 (3.8nM)." [DOI:10.1158/1538-7445.am2023-2796]; target: "The median unbound concentrations of ZN-c3 were 315 nmol/L and 15 nmol/kg in plasma and tumor tissue, respectively - higher than the biochemical IC50 of ZN-c3 for inhibition of WEE1 (3.8nM)." [DOI:10.1158/1538-7445.am2023-2796]; developer: "1Barrow Neurological Institute, Phoenix, AZ." [DOI:10.1158/1538-7445.am2023-2796]; stage: "In this study, we evaluated the efficacy as well as pharmacokinetic and pharmacodynamic properties of ZN-c3, a best-in-class WEE1 inhibitor, in orthotopic patient-derived xenograft (PDX) models of GBM." [DOI:10.1158/1538-7445.am2023-2796]
02
Targets
WEE1 (WEE1 G2 checkpoint kinase)
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