zolimidine

Zolimidine is a small molecule imidazo[1,2-a]pyridine derivative that functions as a gastroprotective and antiulcer agent. Historically marketed for the treatment of peptic, gastric, and duodenal ulcers, it is classified as a "cytoprotective" drug. Its primary mechanism involves increasing the secretion of gastric mucus—specifically the protein component—and modifying gastric proteoglycans to reinforce the mucosal barrier against damage from stomach acid and pepsin. Unlike H2-receptor antagonists or proton pump inhibitors, zolimidine does not significantly alter basal or stimulated gastric acid output. In addition to its clinical use, zolimidine is frequently used in organic chemistry as a model substrate for developing new synthetic methodologies, such as C-H arylation and functionalization of the imidazopyridine scaffold.

Brand names

Solimidin

Other names

zolimidine2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine