Drug intelligence / Profile preview

zolpidem

Development stage
Approved
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral, Sublingual
01

Overview

Zolpidem is a sedative-hypnotic medication used primarily for the short-term treatment of insomnia. It acts as a positive modulator of GABA~A~ receptors, specifically targeting the α1 subunit, which enhances GABAergic inhibition in the central nervous system. This results in strong hypnotic effects with minimal anxiolytic, myorelaxant, and anticonvulsant properties. Zolpidem is effective in reducing sleep onset latency and improving sleep quality but may cause serious sleep behaviors such as sleepwalking or driving while not fully awake.

Brand names
AmbienAmbien CRAdormixEdluarIntermezzoZolpimist
Other names
酒石酸唑吡坦
02

Targets

GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)

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