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zopiclone
- Development stage
- Phase 4
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Zopiclone is a nonbenzodiazepine hypnotic agent from the cyclopyrrolone class, primarily used for the short-term treatment of insomnia in adults. It acts as a positive allosteric modulator at the gamma-aminobutyric acid type A (GABAA) receptor complex, binding to the benzodiazepine site and enhancing GABAergic neurotransmission. This results in sedative, anxiolytic, muscle relaxant, and anticonvulsant effects similar to those of benzodiazepines. Zopiclone is molecularly distinct from benzodiazepines but shares an almost identical pharmacological profile. It is typically prescribed for 2–4 weeks due to risks of tolerance and dependence with longer use[1][2][3][4][5][6]. Developers: Rhône-Poulenc Manufacturers: Sanofi
- Brand names
- ImovaneZimovane
- Other names
- (RS)-zopiclonezopiclonum
02
Targets
GABRR (GABA-A receptor subunit rho)GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)GABRA2 (Gamma-aminobutyric acid receptor subunit alpha 2)GABRA3 (Gamma-aminobutyric acid receptor subunit alpha-3)GABRA5 (Gamma-aminobutyric acid type A receptor subunit alpha-5)
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