Drug intelligence / Profile preview

Zorubicin

Development stage
Unknown
Modality
Small Molecules
Administration
Intravenous
01

Overview

Zorubicin is a benzoylhydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. It exerts its anticancer effects by intercalating into DNA, interacting with and inhibiting topoisomerase II, and inhibiting DNA polymerases. These actions collectively disrupt DNA replication, repair, and the synthesis of RNA and proteins, leading to cell death in various cancer types.

Brand names
RubidazonRubidazoneZorubicine
Other names
benzoyl hydrazone daunorubicindaunorubicin benzoylhydrazone hydrochloride
02

Targets

DNARNAP (Bacterial dna-dependent RNA polymerase)TOP2A (DNA topoisomerase II)DNA polymerase family

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