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ZPIV
- Development stage
- Phase 1
- Lead developer
- Walter Reed Army Institute of Research
- Modality
- Whole Inactivated Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
ZPIV is a purified, formalin-inactivated whole-virus vaccine candidate developed to protect against infection by the Zika virus. It contains chromatographic-column-purified, formalin-inactivated Zika virus strain PRVABC59, including all structural proteins and genomic RNA, and is adjuvanted with aluminum hydroxide (Alhydrogel). The mechanism of action involves stimulating the immune system to produce neutralizing antibodies against the structural proteins of the Zika virus. Preclinical studies demonstrated protection in animal models, and Phase 1 clinical trials have shown that two doses are safe and immunogenic in healthy adults but with limited durability of immune response[1][2][4][7].
- Other names
- Zika purified inactivated virus vaccineZIKV purified inactivated vaccine
02
Targets
ZIKV E (Zika virus envelope protein)
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