Zr-ATP

Zr-ATP is a biomimetic nanoplatform composed of zirconium ions and adenosine triphosphate (ATP) synthesized via a coordination-driven self-assembly approach. Developed as a dual-function radiosensitizer, it is designed to enhance the efficacy of radiotherapy through both physical and biological mechanisms. Physically, the high-atomic-number zirconium ions enhance radiation-induced DNA damage and the generation of reactive oxygen species (ROS). Biologically, Zr-ATP triggers immunogenic cell death (ICD) and pyroptosis, characterized by calreticulin exposure, HMGB1 translocation, and caspase-1 activation. This biological effect is mediated through the activation of the NOD-like receptor (NLR) signaling pathway. Preclinical studies in melanoma-bearing mice have demonstrated that Zr-ATP effectively accumulates in tumors and significantly inhibits tumor growth while prolonging survival when combined with radiotherapy, maintaining a favorable safety profile.

Other names

zirconium-adenosine triphosphate nanoparticleszirconium-engineered nanoplatform