zuclomiphene

Zuclomiphene is a **nonsteroidal estrogen receptor agonist** and the cis-isomer of clomiphene. It has been developed as a small molecule for the treatment of hot flashes in men undergoing androgen deprivation therapy (ADT) for advanced prostate cancer. Zuclomiphene’s mechanism of action is primarily estrogenic, binding to estrogen receptors and exerting weak estrogenic effects; it is distinguished from enclomiphene (the trans-isomer), which is more anti-estrogenic. Zuclomiphene has a notably long half-life compared to its isomer enclomiphene. It is not known to be used outside clinical trials as a single active pharmaceutical ingredient, but it is a component of clomiphene citrate, which is widely used in fertility treatment. Clinical trials have investigated oral zuclomiphene for reducing frequency and severity of hot flashes in prostate cancer patients on ADT[2][4][6].

Other names

zuclomiphene citratecis-Clomiphene citrate