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zuogui granules (044ec6)

Development stage: Unknown
Lead developer: Bing Shu
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Zuogui granules is a Traditional Chinese Medicine (TCM) herbal formulation derived from the classic kidney-Yin-tonifying formula, Zuogui Wan, originally developed by physician Jingyue Zhang during the Ming dynasty. It is composed of eight herbal and animal-derived ingredients: Rehmanniae Radix Praeparata, Dioscoreae Rhizoma, Lycii Fructus, Corni Fructus, Cyathulae Radix, Cuscutae Semen, Cervi Cornus Colla, and Testudinis Carapacis et Plastri Colla. The formulation is designed to nourish kidney essence and is being investigated for the treatment of renal osteodystrophy and chronic renal insufficiency in patients with kidney Yin deficiency. Its mechanism involves regulating bone metabolism by modulating calcium and phosphorus levels, enhancing osteoblast activity, and influencing markers such as fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and osteocalcin.

Other names: Zuogui WanZuogui PillZuogui Keli

Targets

PTH1R (Parathyroid hormone/Parathyroid hormone-related peptide receptor type 1)ALPL (Tissue-nonspecific alkaline phosphatase)FGF23 (Fibroblast growth factor 23)

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