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zuogui wan

Development stage: Unknown
Lead developer: Tianjiang Pharmaceutical
Administration: Oral

Overview

Zuogui Wan is a classic Traditional Chinese Medicine (TCM) formula primarily used to nourish kidney yin and replenish essence. It is traditionally indicated for symptoms of kidney yin deficiency, including lower back and knee soreness, night sweats, fatigue, and dry mouth. Modern clinical and preclinical research has explored its efficacy in treating renal osteodystrophy, osteoporosis, premature ovarian failure, and neuroinflammatory conditions like multiple sclerosis. Its mechanism involves modulating bone metabolism, inhibiting the MAPK signaling pathway (specifically ERK1/2, p38, and JNK), and attenuating microglial M1 polarization to promote remyelination. The formula is manufactured by companies such as Shanghai Lei Yun Shang Pharmaceutical and is widely used in integrative medicine.

Brand names: Zuogui Wan
Other names: Zuogui PillZuo Gui Wan左归丸

Targets

JNK (Mitogen-activated protein kinase kinase kinase family)MAPK3 (Mitogen-activated protein kinase 1)RK (Ribokinase)

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