ZXX-4

ZXX-4 is a novel small molecule inhibitor, structurally characterized as [Sar1, Ile8]-angiotensin II acetate, identified via structure-based virtual screening as a thrombin inhibitor. It exhibits anti-tumor properties, specifically inhibiting thrombin-induced proliferation and metastasis of hepatic carcinoma (HCC) cells in vitro and in vivo, and enhances the efficacy of the standard HCC therapy sorafenib. Its mechanism involves direct inhibition of thrombin, a serine protease implicated in tumor progression, fibrin formation, and platelet activation[1]. ZXX-4 was also previously reported to activate NADPH and NADH oxidases, though its thrombin inhibitory activity represents a novel therapeutic approach for HCC[1].

Other names

[Sar1, Ile8]-angiotensin II acetateZXX-4ZXX4ZXX 4