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ZY19489 + ferroquine
- Development stage
- Phase 1
- Lead developer
- Medicines for Malaria Venture
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ZY19489 + ferroquine is an investigational fixed-dose oral combination therapy for malaria, currently in clinical development. ZY19489 is a fast-killing, blood-stage antimalarial compound with a low propensity to select for resistance and no stable resistance detected in vitro or clinical studies. Ferroquine (FQ, also known as SR97193) is a 4-aminoquinoline derivative and the first organometallic antimalarial drug candidate; it overcomes chloroquine resistance by inhibiting hemozoin formation and generating reactive oxygen species within the parasite's digestive vacuole. The combination aims to provide potent activity against *Plasmodium falciparum* malaria by pairing two agents with distinct mechanisms of action to prevent resistance and maximize efficacy[1][3][4][6].
- Other names
- FQSR97193 (for ferroquine)
02
Targets
β-HematinPlasmodium falciparum asexual blood-stage parasitePfFV heme (Plasmodium falciparum food vacuole heme)
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