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ZYMOX PLUS Advanced Otic
- Development stage
- Unknown
- Lead developer
- Pet King Brands
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Topical
01
Overview
ZYMOX PLUS Advanced Otic is a veterinary topical enzymatic solution developed by Pet King Brands (PKB Animal Health) for the treatment of acute and chronic otitis externa in dogs and cats. The formulation features the patented LP3 Enzyme System—comprising lactoperoxidase, lysozyme, and lactoferrin—which provides broad-spectrum antimicrobial activity against bacteria, fungi, and yeast pathogens. This 'Plus' version is specifically enhanced with four additional biofilm-reducing enzymes (mutanase, dextranase, cellulase, and beta-glucanase) designed to penetrate and degrade the protective microbial biofilms that often contribute to antibiotic resistance and persistent infections. Additionally, the product contains 1% hydrocortisone to provide relief from inflammation, redness, and pruritus. It is marketed as a non-antibiotic alternative that does not require prior ear cleaning, as the enzymes utilize the debris in the ear to facilitate their antimicrobial action.
- Brand names
- ZYMOX PLUS Advanced Otic
- Other names
- ZYMOX PLUS Advanced Otic Enzymatic Solution with 1% Hydrocortisone
02
Targets
PGN (Peptidoglycan)LPO (Lactoperoxidase)GR (Glucocorticoid receptor)
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