Zyn-NP

**Zyn-NP** is a branded nicotine pouch product designed as an alternative to tobacco smoking. It delivers **nicotine** via the oral mucosa when placed between the upper lip and gum for a defined period, typically 30 minutes. The main ingredient is nicotine; the product is tobacco-free, using fillers, flavorings, and stabilizers to create the pouch. In clinical settings, Zyn-NP is used as a comparator for other nicotine pouches to evaluate pharmacokinetics—specifically absorption, maximum plasma concentration, and subjective effects such as craving and satisfaction. Zyn-NP delivers lower maximum plasma nicotine concentrations (Cmax) and total nicotine absorption over time (AUC) compared to similar products, yet demonstrates favorable subjective liking scores[1][2][3]. The developer and main manufacturer is Swedish Match, known for producing Zyn-branded nicotine devices. Zyn-NP's mechanism of action involves **nicotine acting as an agonist at nicotinic acetylcholine receptors**, providing stimulation of the central nervous system, reduction in cigarette craving, and mild euphoria. Primary indication is for **smoking cessation or harm reduction** among nicotine users.

Brand names

Zyn-NP

Other names

Zyn® Cool Mint Mini Dry