Zynamite S

Zynamite S is a proprietary, **water-soluble extract of Mangifera indica (mango) leaf**, standardized to contain 60% mangiferin as its main bioactive compound. Developed as a next-generation, **enhanced-bioavailability version of Zynamite**, it was specifically engineered to overcome the poor solubility and low bioavailability of standard mangiferin preparations. Zynamite S has been clinically shown to rapidly improve cognitive domains such as processing speed, attention, working memory, and executive function, with effects observed within 30 minutes of a single dose and lasting up to 5 hours. Mechanistic studies attribute efficacy largely to partial inhibition of catechol-O-methyltransferase (COMT), increasing dopamine levels in the prefrontal cortex, as well as possible acetylcholinesterase (AChE) inhibition, which could potentiate cholinergic neurotransmission. Unlike stimulant products, Zynamite S exerts these benefits with no effect on heart rate or blood pressure. It also demonstrates **meaningful improvement in mood and reduction of negative emotional states**, making it a dual-action nootropic for both cognitive and emotional performance.

Brand names

Zynamite S

Other names

Zyn-SZynamite water-solubleZynamite S monosodium salt