Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate Receptor Ionotropic AMPA Type Subunit (AMPA Receptor)
- Target
- AMPA Receptor
- Molecular classification
- Ionotropic glutamate receptor, Ligand-gated ion channel, Ion channel
01
Overview
The AMPA receptor is a tetrameric ionotropic glutamate receptor that mediates fast excitatory neurotransmission in the CNS. It is composed of GluA1-4 subunits and is crucial for synaptic plasticity, learning, and memory. Its function is modulated by auxiliary proteins and is implicated in various neurological disorders.
- Other names
- AMPA ReceptorAMPARα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorQuisqualate receptorGluA1GluA2GluA3GluA4GRIA1GRIA2GRIA3GRIA4
02
Mechanism of action
Agonist binding opens the channel pore, allowing Na+ and sometimes Ca2+ influx, leading to depolarization.
03
Biological functions
Fast excitatory neurotransmissionSynaptic plasticityLearningMemoryNeuronal signaling
04
Disease associations
EpilepsyNeurodegenerative diseases (ALS, Alzheimer's disease)Psychiatric conditions (Schizophrenia, Depression)CancerExcitotoxicity
05
Safety considerations
ExcitotoxicityDysregulation can lead to neurological disorders
Beyond the preview
Go deeper on Glutamate Receptor Ionotropic AMPA Type Subunit (AMPA Receptor).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate Receptor Ionotropic AMPA Type Subunit (AMPA Receptor).