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α-amino-3-hydroxy-5-methyl-isoxazolepropionic acid receptor (None)
- Target
- None
- Molecular classification
- Ionotropic glutamate receptor, Receptor, Ligand-gated ion channel
01
Overview
The AMPA receptor (AMPAR) is a ligand-gated ion channel that mediates fast excitatory neurotransmission in the central nervous system (CNS). It is a tetrameric complex composed of GluA1, GluA2, GluA3, and GluA4 subunits. Upon binding glutamate, the channel opens, allowing Na⁺ (and sometimes Ca²⁺) influx, leading to depolarization. AMPARs are crucial for synaptic plasticity, learning, and memory, and are implicated in neurological conditions like epilepsy and autoimmune encephalitis.
- Other names
- AMPA receptorAMPARquisqualate receptor
02
Mechanism of action
Ligand-gated ion channel activation leading to Na⁺ and Ca²⁺ influx and neuronal depolarization
03
Biological functions
Fast excitatory synaptic transmissionSynaptic plasticityLearning and memory
04
Disease associations
EpilepsyAutoimmune limbic encephalitisNeurodegenerative diseases
05
Safety considerations
Excitotoxicity (overactivation leading to neuronal damage)Seizures (overactivation)
06
Interacting drugs
Glutamate
3 more in the full profile.
07
Biomarkers
Autoantibodies against AMPARs (in autoimmune limbic encephalitis)
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