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Target intelligence / Profile preview
α7 Nicotinic Acetylcholine Receptor (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Receptor, Cys-loop receptor superfamily
01
Overview
The α7 nicotinic acetylcholine receptor (α7 nAChR) is a homopentameric ligand-gated ion channel with high calcium permeability and rapid desensitization. It plays a crucial role in synaptic plasticity, neuroprotection, and inflammation regulation via the cholinergic anti-inflammatory pathway. It is implicated in various neuropsychiatric disorders, inflammation, cardiovascular diseases, and cancer, making it a target for therapeutic interventions.
- Other names
- Nicotinic acetylcholine receptor subunit alpha 7Alpha-7 nicotinic receptor
02
Mechanism of action
Activation leads to increased Ca²⁺ influx, modulation of neurotransmitter release, and regulation of synaptic plasticity. Also influences JAK2–STAT3 and AMPK–mTOR signaling pathways.
03
Biological functions
Neurotransmitter release modulationSynaptic plasticity regulationCalcium ion influxNeuroprotectionInflammation regulationCell survivalApoptosis modulationPain modulationAdult neurogenesis
04
Disease associations
Alzheimer’s diseaseSchizophreniaStrokeSepsisAtherosclerosisCardiovascular diseaseCancerAutoimmune diseases
05
Safety considerations
Potential pro-inflammatory effects in specific contexts (e.g., mast cell activation in atherosclerosis)Aberrant expression or activation contributing to cancer progression
06
Interacting drugs
Acetylcholine
5 more in the full profile.
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