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β-Hematin Polymerization

Molecular classification: Other

Overview

β-Hematin polymerization is a critical biochemical process unique to malaria parasites (Plasmodium spp.) that enables them to detoxify free heme released during hemoglobin digestion. The enzyme converts free heme (ferriprotoporphyrin IX) into an insoluble crystalline form called β-hematin (hemozoin). Inhibition of this pathway leads to the accumulation of toxic heme, resulting in parasite death. Thus, it represents a validated drug target for antimalarial therapy.

Other names: Hemozoin formationHeme detoxification pathway

Mechanism of action

Inhibition of β-hematin formation, leading to accumulation of toxic heme within the parasite.

Biological functions

Heme detoxificationParasite survival

Disease associations

Infection

Interacting drugs

Chloroquine

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