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β-Ketoacyl-acyl Carrier Protein Synthase

Molecular classification: Enzyme, Acyltransferase

Overview

β-Ketoacyl-acyl carrier protein (ACP) synthases are essential enzymes in the fatty acid biosynthesis pathway, catalyzing the condensation reactions that elongate fatty acid chains. They are found in both prokaryotes and eukaryotes, with isoforms like KASI, KASII, and KASIII having distinct roles. In bacteria, FabH (KASIII) is a validated target for novel antibacterial agents due to its role in initiating fatty acid synthesis.

Other names: β-Ketoacyl-ACP SynthaseKASKASIKASIIKASIIIFabHβ-Ketoacyl-acp synthase III

Mechanism of action

Inhibition of fatty acid synthesis

Biological functions

Fatty acid biosynthesisLipid metabolismChain elongationCarbon-carbon bond formation

Disease associations

Infection

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