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病原微生物是指能够导致人类、动物或植物发病的各种微生物和类生物的总称,主要包括细菌、病毒、真菌、原生动物、类病毒、朊病毒等[1][3][8]。这些微生物可以通过多种机制引起宿主感染和疾病,例如生产毒素、破坏细胞结构、劫持营养、逃避宿主免疫反应等[1][3][8]。临床上主要针对具体的病原微生物采用抗生素、抗病毒药、抗真菌药或免疫治疗等手段进行治疗。但“病原微生物”本身并不是严格意义上的“分子靶点”,而是一个高度宏观、生物分类意义上的术语。实际药物开发和靶点研究需细分到具体微生物及其分子(如 HIV 逆转录酶、革兰氏阳性细菌细胞壁合成酶等)[1][3][8]。
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