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1→3-beta-D-glucan synthase
- Molecular classification
- Enzyme, Glycosyltransferase, GT48
01
Overview
1→3-beta-D-glucan synthase is a membrane-bound enzyme complex responsible for synthesizing (1,3)-β-D-glucan, a major structural polysaccharide in the fungal cell wall. This enzyme is essential for fungal viability and serves as a key pharmacological target for antifungal drugs such as echinocandins and ibrexafungerp. It catalyzes the polymerization of UDP-glucose to form linear (1,3)-β-D-glucan chains, which provides rigidity and integrity to the fungal cell wall. The main catalytic subunit in S. cerevisiae is Fks proteins (FKS1/FKS2).
- Other names
- GS-IIParamylon synthetaseCallose synthaseFks
02
Mechanism of action
Noncompetitively inhibits the enzyme by binding to specific regions on Fks subunits, disrupting cell wall synthesis
03
Biological functions
Cell wall biosynthesisMorphogenesisStress responseCatalyzes the polymerization of UDP-glucose to form linear (1,3)-β-D-glucan chains
04
Disease associations
Infection
05
Interacting drugs
Echinocandins (caspofungin, anidulafungin, micafungin)
1 more in the full profile.
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