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1,3-beta-D-glucan synthase component FKS1
- Molecular classification
- Enzyme, Glycosyltransferase, Integral membrane protein
01
Overview
FKS1 is the catalytic subunit of the 1,3-beta-D-glucan synthase complex, an integral membrane protein essential for synthesizing β-1,3-glucan—a major structural polysaccharide in fungal cell walls. This enzyme uses UDP-glucose as a substrate to catalyze the formation of β(1→3) glycosidic linkages in glucans. It is a key target for echinocandin-class antifungal drugs like caspofungin. Mutations within FKS1, such as S643P, confer resistance to these drugs.
02
Mechanism of action
Inhibition of β(1→3)-glucan synthesis
03
Biological functions
Cell wall biosynthesisCell wall integrityRegulation of cell sizeMorphogenesis
04
Disease associations
Infection
05
Safety considerations
Development of resistance mutations (e.g., S643P) in FKS1
06
Interacting drugs
Caspofungin
1 more in the full profile.
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