1-acylglycerol-3-phosphate O-acyltransferase 1 (AGPAT1)

1-acylglycerol-3-phosphate O-acyltransferase 1 (AGPAT1) is a membrane-bound enzyme that resides mainly in the endoplasmic reticulum and catalyzes the acylation of lysophosphatidic acid at the sn-2 position, producing phosphatidic acid, a precursor for key phospholipids and diacylglycerol. AGPAT1 is widely expressed in most tissues and has essential physiological roles in lipid biosynthesis, cellular energy handling, and membrane production. It has documented involvement in metabolic, neurological, and reproductive processes and is linked to disorders such as lipodystrophy and certain cancers. AGPAT1 is being explored as a therapeutic target in diseases associated with disordered lipid metabolism and cell signaling

Other names

1-acyl-sn-glycerol-3-phosphate acyltransferase alphaAGPAT1G151-AGP acyltransferase 11-AGPAT 1LPAAT-alphaLPLAT1Lysophosphatidic acid acyltransferase alphaProtein G15epididymis secretory sperm binding proteinlysophospholipid acyltransferaselysophospholipid acyltransferase l

Drugs targeting AGPAT1 would likely inhibit or modulate the enzyme’s acyltransferase activity, thereby altering the biosynthesis of PA and downstream lipid signaling/metabolism. Modulation may result in changes in cell membrane composition, energy storage, and cellular signaling relevant to proliferation in cancer.