1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2) (PLCH2)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2) is a member of the phospholipase C (PLC) family, specifically the eta subfamily, which is characterized by a unique C-terminal domain (UniProt: Q8IVC7). It functions as an enzyme that catalyzes the calcium-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (NCBI Gene: 155061). These products are essential for intracellular calcium mobilization and the activation of protein kinase C, facilitating various signal transduction pathways. PLCH2 is predominantly expressed in the retina and specific regions of the brain, such as the cerebellum and hippocampus, indicating a specialized role in sensory and neuronal signaling (PubMed: 15159411). Research suggests its involvement in the regulation of neurite outgrowth and potentially in the pathophysiology of certain cancers and neurological disorders (PubMed: 24333146). Currently, there are no approved drugs specifically targeting PLCH2, though it remains a target of interest for modulating calcium-sensitive signaling in specific tissues. Its high expression in the visual system suggests it may play a role in phototransduction or retinal maintenance.

Other names

Phospholipase C-eta-2PLC-eta-2Phosphoinositide phospholipase C-eta-2Phospholipase C-like protein 4PLC-L4

Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) in a calcium-dependent manner.