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Target intelligence / Profile preview
11-beta-hydroxysteroid dehydrogenase (11β-HSD)
- Target
- 11β-HSD
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
11-beta-hydroxysteroid dehydrogenase (11β-HSD) refers to a family of enzymes that catalyze the interconversion between active and inactive glucocorticoids, specifically converting cortisol (active) to cortisone (inactive), and vice versa. This process regulates the access of glucocorticoids to their receptors, thereby modulating their physiological effects. There are two main isozymes: Type 1 (HSD-11β1) and Type 2 (HSD-11β2). HSD-11β1 predominantly acts as a reductase, converting cortisone to cortisol, and is highly expressed in the liver and adipose tissue. HSD-11β2 functions as a dehydrogenase, converting cortisol to cortisone, and is primarily expressed in mineralocorticoid target tissues like the kidney and placenta. These isozymes play crucial roles in glucocorticoid regulation, electrolyte balance, and glucose metabolism. Dysregulation of these enzymes can lead to various diseases, including apparent mineralocorticoid excess syndrome, obesity, and metabolic syndrome.
- Other names
- HSD-11βHSD11B
02
Mechanism of action
Inhibition of 11β-HSD activity, modulation of cortisol/cortisone interconversion
03
Biological functions
Glucocorticoid metabolismMineralocorticoid regulationSteroid hormone regulationRedox reactionRegulation of cortisol/cortisone levels
04
Disease associations
HypertensionApparent mineralocorticoid excess syndromeObesityInsulin resistanceMetabolic syndromeAge-related diseases
05
Safety considerations
HypertensionHypokalemiaHyperaldosteronism-like symptoms with excessive glycyrrhizinic acid consumption
06
Interacting drugs
Glycyrrhizinic acid
1 more in the full profile.
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