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Target intelligence / Profile preview
11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
- Target
- 11β-HSD1
- Molecular classification
- Enzyme, Oxidoreductase, Short-chain dehydrogenases/reductases
01
Overview
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a microsomal enzyme that interconverts inactive cortisone and active cortisol, primarily acting as a reductase in vivo. It plays a crucial role in regulating local tissue levels of active glucocorticoids, influencing glucose and lipid metabolism, immune response, and stress responses. Overactivity is linked to metabolic disorders, while inhibitors are being explored as potential therapeutics.
- Other names
- HSD11B111-beta-HSD1
02
Mechanism of action
Inhibition of 11β-HSD1 activity, reducing local cortisol production.
03
Biological functions
Steroid hormone metabolismRegulation of glucose metabolismRegulation of lipid metabolismImmune response modulationStress responsesGlucocorticoid receptor activation
04
Disease associations
ObesityInsulin resistanceMetabolic syndromeType 2 diabetes mellitusOsteoporosisGlaucomaAlzheimer’s diseaseDepressionHyperandrogenism
05
Safety considerations
Excessive inhibition can lead to abnormal hypothalamic-pituitary-adrenal axis responses.Inhibition may cause apparent mineralocorticoid excess syndrome due to increased cortisol levels acting on mineralocorticoid receptors.
06
Interacting drugs
Carbenoxolone
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