Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
- Target
- HSD11B2
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
HSD11B2 is an enzyme that regulates local glucocorticoid activity by converting active cortisol to inactive cortisone. This protects the mineralocorticoid receptor from being activated by cortisol, ensuring aldosterone's primary role in regulating electrolyte balance and blood pressure. Deficiency or inhibition leads to apparent mineralocorticoid excess syndrome.
- Other names
- AMEAME1HSD11KHSD2SDR9C3hydroxysteroid (11-beta) dehydrogenase 2
02
Mechanism of action
Catalyzes the conversion of cortisol to cortisone, reducing cortisol's binding to the mineralocorticoid receptor
03
Biological functions
Regulation of glucocorticoid activityElectrolyte homeostasisBlood pressure regulationProtection of mineralocorticoid receptor
04
Disease associations
HypertensionApparent mineralocorticoid excess syndromeMetabolic disorders
05
Safety considerations
Inhibition can lead to apparent mineralocorticoid excess syndrome (hypertension, hypokalemia, metabolic alkalosis)
06
Interacting drugs
Glycyrrhizinic acid (Licorice)
Beyond the preview
Go deeper on 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2).