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Target intelligence / Profile preview
14α-lanosterol demethylase
- Molecular classification
- Enzyme, Cytochrome P450
01
Overview
14α-lanosterol demethylase (CYP51A1) is a cytochrome P450 enzyme that catalyzes the oxidative removal of the 14α-methyl group from lanosterol, an essential step in the conversion of lanosterol to cholesterol in animals and ergosterol in fungi. It is a key target for azole antifungal drugs, which inhibit ergosterol synthesis in fungi.
- Other names
- Lanosterol 14α-demethylaseCYP51A1CYP51P45014DM
02
Mechanism of action
Inhibition of ergosterol synthesis by binding to the heme iron in the active site.
03
Biological functions
Cholesterol/ergosterol biosynthetic processOxidation-reduction processCellular response to drugSteroid/sterols bindingHeme bindingIron ion bindingSteroid/sterols monooxygenase activity
04
Disease associations
InfectionCancer
05
Safety considerations
Potential for off-target effects due to structural similarity with other cytochrome P450 enzymes.Drug resistance in fungi due to mutations in CYP51A1.Lack of potency/selectivity against human forms compared with microbial ones.
06
Interacting drugs
Imidazoles
2 more in the full profile.
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