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14-3-3 Protein
- Molecular classification
- Scaffolding protein, Adaptor protein
01
Overview
The 14-3-3 protein family is a highly conserved group of regulatory molecules found in eukaryotic cells. Functioning as scaffolding or adaptor proteins, they modulate the activity, localization, and interactions of target proteins, including kinases, phosphatases, transmembrane receptors, and transcription factors. Dysregulation of 14-3-3 proteins is implicated in diseases such as cancer, neurological disorders, rheumatoid arthritis, and viral infections. They represent promising drug targets due to their numerous binding partners and roles in various cellular processes.
- Other names
- 14-3-3 proteinsYWHABYWHAGYWHAEYWHAHSFNYWHAQYWHAZ
02
Mechanism of action
Modulation of protein-protein interactions through phosphoserine/phosphothreonine binding; alteration of conformation/activity; subcellular relocalization; protection from dephosphorylation/degradation
03
Biological functions
Cell cycle progressionApoptosis regulationSignal transductionEnergy metabolismProtein traffickingStress responsesClass switch recombinationCytoskeletal organizationUbiquitination pathwaysDNA/RNA binding protein regulation
04
Disease associations
CancerNeurological disordersRheumatoid arthritisViral infectionNeurodegenerative disorders
05
Safety considerations
Dysregulation implicated in various diseasesInvolvement in both oncogenic and tumor suppressor functions in cancer
06
Biomarkers
eta isoform (YWHAH) for rheumatoid arthritisPrion diseases
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